Interleukin-6

NameInterleukin-6
Synonyms
  • B-cell stimulatory factor 2
  • BSF-2
  • CDF
  • CTL differentiation factor
  • Hybridoma growth factor
  • IFN-beta-2
  • IFNB2
  • IL-6
  • Interferon beta-2
Gene NameIL6
OrganismHuman
Amino acid sequence
>lcl|BSEQ0021838|Interleukin-6
MNSFSTSAFGPVAFSLGLLLVLPAAFPAPVPPGEDSKDVAAPHRQPLTSSERIDKQIRYI
LDGISALRKETCNKSNMCESSKEALAENNLNLPKMAEKDGCFQSGFNEETCLVKIITGLL
EFEVYLEYLQNRFESSEEQARAVQMSTKVLIQFLQKKAKNLDAITTPDPTTNASLLTKLQ
AQNQWLQDMTTHLILRSFKEFLQSSLRALRQM
Number of residues212
Molecular Weight23717.965
Theoretical pI6.52
GO Classification
Functions
  • growth factor activity
  • cytokine activity
  • interleukin-6 receptor binding
Processes
  • response to drug
  • negative regulation of lipid storage
  • cytokine-mediated signaling pathway
  • epithelial cell proliferation involved in salivary gland morphogenesis
  • cellular response to hydrogen peroxide
  • response to electrical stimulus
  • response to antibiotic
  • response to auditory stimulus
  • positive regulation of DNA replication
  • regulation of circadian sleep/wake cycle, non-REM sleep
  • cellular response to tumor necrosis factor
  • response to caffeine
  • monocyte chemotaxis
  • positive regulation of protein import into nucleus, translocation
  • response to insulin
  • muscle cell cellular homeostasis
  • positive regulation of transcription, DNA-templated
  • negative regulation of hormone secretion
  • endocrine pancreas development
  • negative regulation of gluconeogenesis
  • neuron projection development
  • defense response to Gram-positive bacterium
  • negative regulation of apoptotic process
  • positive regulation of MAPK cascade
  • response to heat
  • positive regulation of T-helper 2 cell differentiation
  • positive regulation of epithelial cell proliferation
  • defense response to virus
  • negative regulation of cell proliferation
  • negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
  • positive regulation of tyrosine phosphorylation of Stat3 protein
  • humoral immune response
  • response to peptidoglycan
  • positive regulation of ERK1 and ERK2 cascade
  • positive regulation of JAK-STAT cascade
  • defense response to protozoan
  • positive regulation of peptidyl-serine phosphorylation
  • response to cold
  • inflammatory response
  • negative regulation of fat cell differentiation
  • positive regulation of smooth muscle cell proliferation
  • cellular response to interleukin-1
  • positive regulation of transcription from RNA polymerase II promoter
  • positive regulation of protein kinase B signaling
  • neutrophil mediated immunity
  • positive regulation of neuron differentiation
  • negative regulation of neuron death
  • acute-phase response
  • positive regulation of immunoglobulin secretion
  • cell growth
  • interleukin-6-mediated signaling pathway
  • response to amino acid
  • positive regulation of sequence-specific DNA binding transcription factor activity
  • positive regulation of cell proliferation
  • positive regulation of transmission of nerve impulse
  • regulation of cell shape
  • regulation of angiogenesis
  • regulation of vascular endothelial growth factor production
  • positive regulation of interleukin-6 production
  • negative regulation of chemokine biosynthetic process
  • platelet activation
  • hepatic immune response
  • defense response to Gram-negative bacterium
  • positive regulation of STAT protein import into nucleus
  • response to calcium ion
  • response to yeast
  • cell redox homeostasis
  • negative regulation of collagen biosynthetic process
  • positive regulation of chemokine production
  • positive regulation of leukocyte chemotaxis
  • response to glucocorticoid
  • positive regulation of translation
  • negative regulation of protein kinase activity
  • glucagon secretion
  • positive regulation of T cell proliferation
  • positive regulation of acute inflammatory response
  • response to nutrient levels
  • positive regulation of nitric oxide biosynthetic process
  • glucose homeostasis
  • negative regulation of muscle organ development
  • positive regulation of osteoblast differentiation
  • positive regulation of B cell activation
  • cellular response to lipopolysaccharide
  • neutrophil apoptotic process
  • positive regulation of apoptotic process
  • positive regulation of type B pancreatic cell apoptotic process
  • aging
  • negative regulation of cytokine secretion
  • bone remodeling
  • branching involved in salivary gland morphogenesis
  • positive regulation of peptidyl-tyrosine phosphorylation
  • T-helper 17 cell lineage commitment
  • cellular response to dexamethasone stimulus
Components
  • external side of plasma membrane
  • extracellular space
  • interleukin-6 receptor complex
  • cytoplasm
  • extracellular region
General FunctionInterleukin-6 receptor binding
Specific FunctionCytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasmacytoma growth and induces nerve cells differentiation.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein ID32674
UniProtKB IDP05231
UniProtKB Entry NameIL6_HUMAN
Cellular LocationSecreted
Gene sequence
>lcl|BSEQ0021839|Interleukin-6 (IL6)
ATGAACTCCTTCTCCACAAGCGCCTTCGGTCCAGTTGCCTTCTCCCTGGGGCTGCTCCTG
GTGTTGCCTGCTGCCTTCCCTGCCCCAGTACCCCCAGGAGAAGATTCCAAAGATGTAGCC
GCCCCACACAGACAGCCACTCACCTCTTCAGAACGAATTGACAAACAAATTCGGTACATC
CTCGACGGCATCTCAGCCCTGAGAAAGGAGACATGTAACAAGAGTAACATGTGTGAAAGC
AGCAAAGAGGCACTGGCAGAAAACAACCTGAACCTTCCAAAGATGGCTGAAAAAGATGGA
TGCTTCCAATCTGGATTCAATGAGGAGACTTGCCTGGTGAAAATCATCACTGGTCTTTTG
GAGTTTGAGGTATACCTAGAGTACCTCCAGAACAGATTTGAGAGTAGTGAGGAACAAGCC
AGAGCTGTGCAGATGAGTACAAAAGTCCTGATCCAGTTCCTGCAGAAAAAGGCAAAGAAT
CTAGATGCAATAACCACCCCTGACCCAACCACAAATGCCAGCCTGCTGACGAAGCTGCAG
GCACAGAACCAGTGGCTGCAGGACATGACAACTCATCTCATTCTGCGCAGCTTTAAGGAG
TTCCTGCAGTCCAGCCTGAGGGCTCTTCGGCAAATGTAG
GenBank Gene IDX04430
GeneCard IDNot Available
GenAtlas IDIL6
HGNC IDHGNC:6018
Chromosome Location7
Locus7p21
References
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