1810 Vinyl bromide Vinyl bromide is an organobromide compound. It is used to manufacture bromopolymers, mainly polyvinyl bromide, and is also an alkylation agent. Vinyl bromide is primarily used in the manufacture of flame retardant synthetic fibers. Its copolymer with vinyl chloride is also used for preparing films, for laminating fibers, and as rubber substitutes. Vinyl bromide is highly flammable liquid and reacts violently with oxidizers. 593-60-2 11641 C2H3Br 105.941810 Colorless gas. -137.8°C Oral (L626) ; inhalation (L626) ; dermal (L626) Organobromide compounds, especially alkylbromides are strong alkylating agents. Consequently they can randomly modify the surfaces of proteins and lipids, leading to the disruption of enzyme, transporter or membrane functions. Alkylation of DNA by alkylbromides may also lead to mutations. Vinyl bromide is metabolically activated by liver microsomal enzymes to intermediates that covalently bind to proteins and nucleic acids. Several lines of evidence suggest the involvement of the epoxides, i.e., bromoethylene oxide. Proven targets for alkylation are adenine, cytosine and guanine moieties in nucleic acids, and sulfhydryl groups of proteins. Vinylbromide reacts quickly with hepatic glutathione (GSH) leading to its rapid depletion and subsequent liver damage. Bromine is mainly absorbed via inhalation, but may also enter the body through dermal contact. Bromine salts can be ingested. Due to its reactivity, bromine quickly forms bromide and may be deposited in the tissues, displacing other halogens. (L626) LD50: 500 mg/kg (Oral, Rat) (T20) 2A, probably carcinogenic to humans. (L135) Vinyl bromide is primarily used in the manufacture of flame retardant synthetic fibers. Workers may be occupationally exposed to vinyl bromide via inhalation during its manufacture or use. Acute (short-term) and chronic (long-term) studies indicate that the liver is the primary target organ following inhalation exposure to vinyl bromide in humans and animals. Acute exposure of rats to very high concentrations via inhalation has resulted in liver and kidney damage and adverse neurological effects. Chronic inhalation exposure primarily damages the liver, causing foci in the liver of rats. Vinyl bromide has been shown to be a potent carcinogen in rats exposed by inhalation, producing liver angiosarcomas. In high concentrations, vinyl bromide may produce dizziness, disorientation, and sleepiness in humans. EYES: irrigate opened eyes for several minutes under running water. INGESTION: do not induce vomiting. Rinse mouth with water (never give anything by mouth to an unconscious person). Seek immediate medical advice. SKIN: should be treated immediately by rinsing the affected parts in cold running water for at least 15 minutes, followed by thorough washing with soap and water. If necessary, the person should shower and change contaminated clothing and shoes, and then must seek medical attention. INHALATION: supply fresh air. If required provide artificial respiration. 2009-06-22T16:08:38Z 2014-12-24T20:24:40Z C19184 51311 11-DCE C003763 Vinyl bromide 1464 true BrC=C C2H3Br InChI=1S/C2H3Br/c1-2-3/h2H,1H2 InChIKey=INLLPKCGLOXCIV-UHFFFAOYSA-N 106.949 105.941812743 Exogenous Gas 11151