2548 Charybdotoxin Charybdotoxin is a peptide toxin produced by the Yellow scorpion (Leiurus quinquestriatus hebraeus). It is a neurotoxin that blocks calcium-activated potassium channels.This blockade causes hyperexcitability of the nervous system. It is a close homologue of agitoxin and both toxins come from Leiurus quinquestriatus hebraeus. (L1041) 95751-30-7 44134622 6673.889999999996 Clear solution. >10 mg/mL Injection (sting/bite) (L1813) Charybdotoxin is a neurotoxin that blocks calcium-activated and voltage gated potassium channels by binding to one of four independent, overlapping binding sites. This results in neuronal hyperexcitability. (T170, L1041) Free toxin may be removed by opsonization via the reticuloendothelial system (primarily the liver and kidneys) or it may be degraded through cellular internalization via the lysosomes. Lysosomes are membrane-enclosed organelles that contain an array of digestive enzymes, including several proteases. LD50: 0.25 mg/kg (Subcutaneous, Mouse) (T255) No indication of carcinogenicity to humans (not listed by IARC). Charybdotoxin is a peptide toxin produced by the Yellow scorpion (Leiurus quinquestriatus hebraeus). (L1041) Stings from the Yellow scorpion are painful but not usually fatal. However, in some cases envenomation may cause anaphylaxis, a potentially life-threatening allergic reaction to the venom. (L1042) Stings from the Yellow scorpion are painful but not usually fatal. (L1042) An antivenom exists for Leiurus quinquestriatus stings. (L1044) 2009-07-03T22:19:03Z 2014-12-24T20:25:38Z P13487 Charybdotoxin 1BAH true Exogenous Liquid 4jta_bio_r_500.jpg image/jpeg 98147 2014-10-14T18:12:52Z BSEQ0008436