2580 Calciseptine Calciseptine is a peptide toxin produced by the Black mamba (Dendroaspis polylepis polylepis). It is a smooth muscle relaxant and an inhibitor of cardiac contractions. (T170) 134710-25-1 7044.154999999995 Clear solution. >10 mg/mL Injection (sting/bite) (L1814) Calciseptine is a specific blocker of the L-type calcium channel, and as a result also a smooth muscle relaxant and an inhibitor of cardiac contractions. (T170) Free toxin may be removed by opsonization via the reticuloendothelial system (primarily the liver and kidneys) or it may be degraded through cellular internalization via the lysosomes. Lysosomes are membrane-enclosed organelles that contain an array of digestive enzymes, including several proteases. LD50: 0.32 mg/kg (Subcutaneous, Mouse) (L1830) LD50: 0.25 mg/kg (Intravenous, Mouse) (L1830) LD50: 0.941 (Intraperitoneal, Mouse) (L1830) No indication of carcinogenicity to humans (not listed by IARC). Calciseptine is a peptide toxin produced by the Black mamba (Dendroaspis polylepis polylepis). (T170) Calciseptine is neurotoxic. (L1716) Bites from snakes in the Elapidae family produce pain at the site of the bite, followed by drowsiness, weakness, excessive salivation, decreased blood pressure, difficulty breathing, and paralysis of the facial muscles, lips, tongue, and larynx. In addition, ptosis, blurring of vision, convulsions, and headache may occur. (T156) An antivenom exists for Black mamba venom. (L1044) 2009-07-03T22:19:16Z 2014-12-24T20:25:40Z P22947 true Exogenous Liquid 1tfs_asym_r_500.jpg image/jpeg 42729 2014-10-14T18:13:10Z BSEQ0008458