2642 Perfringolysin O Perfringolysin O (PFO) or theta-toxin is produced by Clostridium perfringens. It is a member of the cholesterol-dependent cytolysin family. (A2832) 71329-60-7 55829.40499999994 Clear solution. >10 mg/mL Ingestion (L1816) ; inhalation (L1816) ; dermal (L1816) Perfringolysin O binds to cholesterol on eukaryotic cell membranes, then forms oligomeric pores. This causes membrane damage and lysis of the cell. (A2832) Free toxin may be removed by opsonization via the reticuloendothelial system (primarily the liver and kidneys) or it may be degraded through cellular internalization via the lysosomes. Lysosomes are membrane-enclosed organelles that contain an array of digestive enzymes, including several proteases. LD50: 13-16 ug/mg (Intravenous, Mouse) (A2855) No indication of carcinogenicity to humans (not listed by IARC). Perfringolysin O (PFO) is produced by Clostridium perfringens. (A2832) Perfringolysin O (PFO) is produced by Clostridium perfringens. Clostridium perfringens can cause infections producing tissue necrosis and clostridial myonecrosis. Ingestion causes food poisoning. (A2832, L1804) Ingestion of Clostridium perfringens causes food poisoning characterized by colic, diarrhoea and sometimes nausea. Infections show evidence of tissue necrosis, bacteremia, emphysematous cholecystitis, and gas gangrene, which is also known as clostridial myonecrosis. (L1804) Clostridium perfringens infections can be treated with antibiotics. (L1804) 2009-07-06T18:11:27Z 2014-12-24T20:25:45Z P0C2E9 Perfringolysin O 1M3I true Exogenous Liquid 1m3i_bio_r_500.jpg image/jpeg 34030 2014-10-14T18:13:32Z BSEQ0008483