2690 Box jellyfish toxin (Chironex fleckeri) Box jellyfish toxin is found in the venom of the Box jellyfish (class Cubozoa), especially Chironex fleckeri, which is known for its powerful and often fatal sting. (L1119) 51389.86499999999 Clear solution. >10 mg/mL Injection (sting/bite) (L1815) Box jellyfish toxin has potent hemolytic activity and may act as a pore-forming toxin, disrupting normal transmembrane ion concentration gradients in susceptible cells. (T170) Free toxin may be removed by opsonization via the reticuloendothelial system (primarily the liver and kidneys) or it may be degraded through cellular internalization via the lysosomes. Lysosomes are membrane-enclosed organelles that contain an array of digestive enzymes, including several proteases. No indication of carcinogenicity to humans (not listed by IARC). Box jellyfish toxin is found in the venom of the Box jellyfish (class Cubozoa), especially Chironex fleckeri. (L1119) The box jellyfish venom has multiple effects, attacking the nervous system, heart and skin at the same time. The box jellyfish sting produces excruciating pain accompanied by an intense burning sensation. (L1119) Box jellyfish stings should be doused with vinegar, which inhibits and unactivated nematocysts. Rescue breathing and CPR may be required. For less serious stings, treatment with ice packs and antihistamines is an effective method of pain relief. A box jellyfish antivenom does exist, but it must be administered quickly. (L1119) 2009-07-06T21:35:54Z 2014-12-24T20:25:48Z A7L035 true Exogenous Liquid BSEQ0008513