2930 Propiomazine Propiomazine, an atypical antipsychotic agent, is used to treat both negative and positive symptoms of schizophrenia, acute mania with bipolar disorder, agitation, and psychotic symptoms in dementia. Future uses may include the treatment of obsessive-compulsive disorder and severe behavioral disorders in autism. Structurally and pharmacologically similar to clozapine, propiomazine binds to alpha(1), dopamine, histamine H1, muscarinic, and serotonin type 2 (5-HT2) receptors. 362-29-8 4940 C20H24N2OS 340.160930 White powder. 0.454 mg/L Propiomazine is an antagonist at types 1, 2, and 4 dopamine receptors, serotonin (5-HT) receptor types 2A and 2C, muscarinic receptors 1 through 5, alpha(1)-receptors, and histamine H1-receptors. Its main use as a sedative is due to its antihistamine effect. Unknown, but most likely hepatic as with other phenothiazines. No indication of carcinogenicity to humans (not listed by IARC). Propiomazine is largely used for its antihistamininc sleep inducing effects in treating insomnia. They cause slurred speech, disorientation and "drunken" behavior. They are physically and psychologically addictive. Rare, serious side effects include convulsions (seizures); difficult or unusually fast breathing; fast or irregular heartbeat or pulse; fever (high); high or low blood pressure; loss of bladder control; muscle stiffness (severe); unusual increase in sweating; unusually pale skin; and unusual tiredness or weakness. 2009-07-21T20:27:38Z 2014-12-24T20:25:52Z Propiomazine C07405 8491 Propiomazine DB00777 true CCC(=O)C1=CC2=C(SC3=CC=CC=C3N2CC(C)N(C)C)C=C1 C20H24N2OS InChI=1/C20H24N2OS/c1-5-18(23)15-10-11-20-17(12-15)22(13-14(2)21(3)4)16-8-6-7-9-19(16)24-20/h6-12,14H,5,13H2,1-4H3 InChIKey=UVOIBTBFPOZKGP-UHFFFAOYNA-N 340.482 340.16093409 Exogenous Solid 4.79 HMDB14915 CHEMBL1201210 4771