3120 Aconitine Aconitine is a plant toxin found in species of wolfsbane (Aconitum genus). It is a neurotoxin previously used as an antipyretic and analgesic, and still has some limited application in herbal medicine. (L1235). The toxic effects of Aconitine have been tested in a variety of different test animals, including mammals (dog, cat, guinea pig, mouse, rat and rabbit), frogs and pigeons. Depending on the route of exposure, the observed toxic effects were: local anesthetic effect, diarrhea, convulsions, arrhythmias or death. According to a review of different reports of aconite poisoning in humans the following clinical features were observed: Neurological, Cardiovascular, Ventricular arrhythmias, Gastrointestinal. 302-27-2 245005 C34H47NO11 645.73708 White powder. 204°C 0.31 mg/mL at 25°C [SEIDELL,A (1941)] Oral (ingestion) (L1817) ; dermal (L1817) Aconitine opens voltage-gated sodium channed in the heart and other tissues. (L1235) LD50: 0.166 mg/kg (Intravenous, Mouse) (L1235) LD50: 0.328 mg/kg (Intraperitoneal, Mouse) (L1235) LD50: 1 mg/kg (Oral, Mouse) (L1235) 1.5 to 6 mg for an adult human. (L1235) No indication of carcinogenicity to humans (not listed by IARC). Aconitine is a plant toxin found in species of wolfsbane (Aconitum genus). It is a neurotoxin previously used as an antipyretic and analgesic, and still has some limited application in herbal medicine. (L1235) Aconitine may cause death from respiratory paralysis and cardiac arrest. (L1235) Symptoms of acontine poisoning include paresthesia of the whole body, starting from the extremities, anesthesia, sweating and cooling of the body, nausea, and vomiting. Sometimes there is strong pain, accompanied by cramps, or diarrhea. (L1235) As there is no antidote to acontine, treatment is symptomatic and may include administering atropine, strychnine or barakol. (L1235) 2009-07-23T18:26:06Z 2014-12-24T20:25:57Z C06091 2430 Aconitine true [H][C@@]12C[C@@]3(O)[C@]([H])(OC(=O)C4=CC=CC=C4)[C@]1([H])[C@@](OC(C)=O)([C@@]1([H])[C@]([H])(OC)[C@@]4([H])[C@]22C1([H])N(CC)C[C@]4(COC)[C@]([H])(O)C[C@]2([H])OC)[C@@]([H])(O)[C@]3([H])OC C34H47NO11 InChI=1S/C34H47NO11/c1-7-35-15-31(16-41-3)20(37)13-21(42-4)33-19-14-32(40)28(45-30(39)18-11-9-8-10-12-18)22(19)34(46-17(2)36,27(38)29(32)44-6)23(26(33)35)24(43-5)25(31)33/h8-12,19-29,37-38,40H,7,13-16H2,1-6H3/t19-,20?,21+,22-,23+,24+,25-,26?,27+,28-,29+,31+,32-,33+,34-/m1/s1 InChIKey=XFSBVAOIAHNAPC-BHMXGGQCSA-N 645.7371 645.314911351 Exogenous Solid CHEMBL1979562 214292