3814 Fumagillin Fumagillin is a mycotoxin found in the fungus Aspergillus fumigatus. It is an antimicrobial agent and amebicide that has been used in the treatment of microsporidiosis and other infections, especially in immunodeficient patients. It also has been investigated as a angiogenesis inhibitor in the treatment of cancer. Since fumagillin is often used to treat microsporidiosis in bees, it can be found as a contaminant in honey. (L1966, A3058) 23110-15-8 6436022 C26H34O7 White powder. Oral, dermal, inhalation, and parenteral (contaminated drugs). (A3101) Fumagillin blocks blood vessel formation (angiogenesis) by inhibiting the enzyme methionine aminopeptidase 2. This prevents angiogenesis by arresting endothelial cells in the G1 phase of the cell cycle. Inhibition of angiogenesis can suppress tumor growth and metastasis. Methionine aminopeptidase 2 inhibition also blocks Wnt signaling, which plays a critical role in development, cell differentiation, and tumorigenesis. (A3059, A3060) No indication of carcinogenicity to humans (not listed by IARC). Fumagillin is a mycotoxin found in the fungus Aspergillus fumigatus. It is an antimicrobial agent and amebicide that has been used in the treatment of microsporidiosis and other infections, especially in immunodeficient patients. It also has been investigated as a angiogenesis inhibitor in the treatment of cancer. Since fumagillin is often used to treat microsporidiosis in bees, it can be found as a contaminant in honey. (L1966, A3058) Fumagillin can be genotoxic, clastogenic, and cytotoxic. It may also cause thrombocytopenia, neutropenia and hyperlipasaemia. (A3058, A3061, A3062) Fumagillin may cause abdominal cramps, vomiting, and diarrhea. (A3062) 2010-05-19T15:34:28Z 2014-12-24T20:26:30Z http://en.wikipedia.org/wiki/Fumagillin DB02640 true COC1C(CCC2(CO2)C1C1(C)OC1CC=C(C)C)OC(=O)C=CC=CC=CC=CC(O)=O C26H34O7 InChI=1S/C26H34O7/c1-18(2)13-14-20-25(3,33-20)24-23(30-4)19(15-16-26(24)17-31-26)32-22(29)12-10-8-6-5-7-9-11-21(27)28/h5-13,19-20,23-24H,14-17H2,1-4H3,(H,27,28)/b7-5+,8-6+,11-9+,12-10+ InChIKey=NGGMYCMLYOUNGM-HCNIIHBUSA-N 458.544 458.230453442 Exogenous Solid <p>Peterson, M.H., Goldstein, A.W. and Denison, F.W. Jr.; U.S. Patent 2,803,586; August 20, 1957; assigned to Abbott Laboratories.</p>