3897 Fluazinam Fluazinam is a broad-spectrum fungicide used in agriculture. It is classed as a diarylamine and more specifically an arylaminopyridine. The mode of action involves the compound being an extremely potent uncoupler of oxidative phosphorylation in mitochondria and also having high reactivity with thiols. It is unique amongst uncouplers in displaying broad-spectrum activity against fungi and also very low toxicity to mammals due to it being rapidly metabolised to a compound without uncoupling activity. Fluazinam is a protectant fungicide, but is neither systemic or curative. It acts by inhibiting the germination of spores and the development of infection structures. Although it has activity against many fungi, it is less potent against rusts and powdery mildew and as such has not been commercialised for use in cereal crops. It is widely used to control late blight (P. infestans) in potato due to its activity against the zoospores of the pathogen which makes it particularly effective at controlling infection of the potato tubers. 79622-59-6 91731 C13H4Cl2F6N4O4 White powder. Inhalation and dermal contact. Not listed by IARC. This is a man-made compound that is used as a pesticide. Fluazinam increases the risks of thyroid gland follicular cell and hepatocellular tumors in rats and mice. According to The Cancer Assessment Review Committee (CARC), there is suggestive evidence of carcinogenicity, but not sufficient to assess human carcinogenic potential. Fluazinam can cause eye irritation and moderate skin sensitization. 2013-04-25T07:56:51Z 2014-12-24T20:26:33Z C18578 true [O-][N+](=O)C1=CC(=C(Cl)C(=C1NC1=C(Cl)C=C(C=N1)C(F)(F)F)[N+]([O-])=O)C(F)(F)F C13H4Cl2F6N4O4 InChI=1S/C13H4Cl2F6N4O4/c14-6-1-4(12(16,17)18)3-22-11(6)23-9-7(24(26)27)2-5(13(19,20)21)8(15)10(9)25(28)29/h1-3H,(H,22,23) InChIKey=UZCGKGPEKUCDTF-UHFFFAOYSA-N 465.092 463.95137928 Exogenous Solid CHEMBL1878267 82831