4115 Veratridine Veratridine is a steroid-derived alkaloid from plants in the Liliaceae family that functions as a neurotoxin by activating sodium ion channels. It is primarily obtained from the herb Veratrum and sabadilla seeds. It binds to intramembrane receptor site 2 and increases intracellular Ca2+ concentration. It acts by preferentially binding to activated Na+ channels causing persistent activation that leads to increased nerve excitability. 71-62-5 441081 C36H51NO11 White powder. Veratridine is a steroid-derived alkaloid from plants in the Liliaceae family that functions as a neurotoxin by abolishing inactivation of sodium ion channels. It binds to intramembrane receptor site 2 and increases intracellular Ca2+ concentration. It acts by preferentially binding to activated Na+ channels causing persistent activation that leads to increased nerve excitability. (Wikipedia) The activation of the action potential Na+ ionophore by veratridine is time- and concentrationdependent and completely reversible. (A15424) No indication of carcinogenicity to humans (not listed by IARC). Veratridine is a steroid-derived alkaloid from plants in the Liliaceae family that functions as a neurotoxin by activating sodium ion channels. 2014-08-29T05:00:13Z 2014-12-24T20:26:37Z C06544 true [H]C12CCC3([H])[C@]4(O)C[C@]([H])(O)[C@@]5(O)C([H])(CN6CC([H])(C)CCC6([H])[C@@]5(C)O)[C@]4(O)C[C@@]33O[C@]1(O)C([H])(CCC23C)OC(=O)C1=CC(OC)=C(OC)C=C1 C36H51NO11 InChI=1S/C36H51NO11/c1-19-6-11-26-31(3,40)35(43)25(17-37(26)16-19)33(42)18-34-24(32(33,41)15-27(35)38)10-9-23-30(34,2)13-12-28(36(23,44)48-34)47-29(39)20-7-8-21(45-4)22(14-20)46-5/h7-8,14,19,23-28,38,40-44H,6,9-13,15-18H2,1-5H3/t19?,23?,24?,25?,26?,27-,28?,30?,31+,32+,33+,34+,35-,36-/m0/s1 InChIKey=FVECELJHCSPHKY-UIHGVQCZSA-N 673.7902 673.346211479 Exogenous Solid 5290571