5038 Isoprenaline Isopropyl analog of epinephrine; beta-sympathomimetic that acts on the heart, bronchi, skeletal muscle, alimentary tract, etc. It is used mainly as bronchodilator and heart stimulant. [PubChem] 7683-59-2 3779 C11H17NO3 180 °C 5.86e+00 g/L The pharmacologic effects of isoproterenol are at least in part attributable to stimulation through beta-adrenergic receptors of intracellular adenyl cyclase, the enzyme that catalyzes the conversion of adenosine triphosphate (ATP) to cyclic AMP. Increased cyclic AMP levels are associated with relaxation of bronchial smooth muscle and inhibition of release of mediators of immediate hypersensitivity from cells, especially from mast cells. No indication of carcinogenicity to humans (not listed by IARC). For the treatment of mild or transient episodes of heart block that do not require electric shock or pacemaker therapy also used in management of asthma and chronic bronchitis 2014-10-14T21:18:14Z 2014-12-24T20:27:01Z Isoproterenol C07056 64317 D007545 DB01064 true CC(C)NCC(O)C1=CC(O)=C(O)C=C1 C11H17NO3 InChI=1/C11H17NO3/c1-7(2)12-6-11(15)8-3-4-9(13)10(14)5-8/h3-5,7,11-15H,6H2,1-2H3 InChIKey=JWZZKOKVBUJMES-UHFFFAOYNA-N 211.2576 211.120843415 Endogenous Solid 1.4 HMDB15197 CHEMBL434 3647 <p>U.S. Patent 2,308,232.<br /> U.S. Patent 2,715,141.</p>